peter w replied: "I have used Aropax ( Paroxetine) for about ten years. For a chronic depression. One thing that should be mentioned is that almost all SSRI's and MAOI's and the new ones have a kick in period. They also differ in the effects that they give individual people and the side effects as well. One thing that I have found with other people is that many GP's and even Psychiatrists prescribe the largest dose. Rather than starting people off small and building up. I have taken 10mg for years (and would like to be able to take 5mg but they don't make a tablet that size.) recently I increased my dose to 20mg as I felt that I was stressed and getting depressed and it made things worse. I have now gone back onto the 10mg dose and feel much better. One thing I have found for me is that the meds work better if I take vitamin C about 1000mg and folic acid with them. I would suggest that if you don't find "drug" which helps you. You look at going to a dietitian or GOOD naturopath. Many times they can help where conventional medication has failed. I have a friend for whom all conventional drugs failed. He tried them all they would work for a period of time long enough for him to get a job and start to get his life together. The longest that any helped was two years. He went to a naturapath and she put him on some dietary supplements and limited some foods or rather the times when he could eat them. ( like coffee he is only allowed before lunch) He has been OK for the last five years. If he comes off the diet or supplements he notices a difference. I suggest that you read up more on these drugs as you will find that the ones that are mentioned in the usa are avaliable in the UK but under a different name try here This page also leads to a lot of other information. It is surprising what you will find. I did this research for myself as I would like to withdraw from medication something that I have tried a number of times before. Hope that this helps"