mtarsier replied: "Domperidone (Systemic)
Description
Domperidone ( dom-PER-i-done) is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Domperidone is to be given only by or under the immediate supervision of your doctor. It is available in the following dosage forms:
* Oral Tablets (Canada)
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For domperidone the following should be considered:
AllergiesTell your doctor if you have ever had any unusual or allergic reaction to domperidone.
PregnancyPregnancydomperidone has not been studied in pregnant women. However, domperidone has not been shown to cause birth defects or other problems in animal studies.
Breast-feeding Breast-feedingDomperidone passes into the breast milk, but it is not known if domperidone will cause unwanted effects in the newborn. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.
ChildrenChildrenStudies on this medicine have been done only in adult patients, and there is no specific information comparing use of domperidone in children with use in other age groups.
Older adultsMany medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of domperidone in the elderly with use in other age groups.
Other medicinesAlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your doctor or pharmacist if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine, especially:
* Monoamine oxidase (MAO) inhibitors (furazolidone [e.g., Furoxone], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegilene [e.g., Eldepryl], tranylcypromine [e.g., Parnate])
Other medical problemsThe presence of other medical problems may affect the use of domperidone. Make sure you tell your doctor if you have any other medical problems, especially:
* Bleeding from the stomach or other problems involving the bowels
* Pituitary (brain) tumor
* Liver disease
* Medicine sensitivity to domperidone
Proper Use of This Medicine
Dosing
The dose of domperidone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of domperidone.If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets of that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking domperidone.
* For oral dosage form (tablets):
o Treatment of gastrointestinal motility disorders:
+ Adults10 milligrams (mg) three to four times daily. Some patients may require higher doses up to 20 mg three or four times daily.
o Nausea and vomiting:
+ Adults20 milligrams (mg) three to four times daily.
Missed dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
To store this medicine:
* Keep out of the reach of children.
* Store away from heat and direct light.
* Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
* Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.
Precautions While Using This MedicineReturn to top
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.
If your symptoms do not improve within a few days or if they become worse, check with your doctor.
Side Effects of This MedicineReturn to top
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Symptoms of overdose
Get emergency help immediately if any of the following symptoms of overdose occur
* Difficulty in speaking; disorientation ; dizziness; fainting; irregular heartbeat; light-headedness ; loss of balance or muscle control
Check with your doctor immediately if any of the following side effects occur:
* Less common
* Loss of balance or muscle control; swelling of the mouth
* Rare
o Fast, irregular, pounding, or racing heartbeat or pulse; swelling of face, hands, lower legs, or feet
. Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.
* Less common
o Breast milk flowing from the nipple; dry mouth; swelling of the breast in the male; headache; hives; hot flashes; itching of skin; itching, redness, pain, or swelling of eye; menstrual irregularities; pain in the breast
Rare
* Change in need to urinate; change in appetite; constipation; diarrhea; burning, difficult, or painful urination ; difficulty in speaking ; dizziness; drowsiness; heartburn; irritability; lack or loss of strength; leg cramps; mental dullness; nervousness; palpitations; sluggishness; stomach cramps; thirst; tiredness; weakness
Brand Names
In Canada
* Motilium
Category
* Anti-emetic
* Dopaminergic blocking agent
Sucralfate
Why is this medication prescribed?
Sucralfate is used to treat ulcers. It adheres to damaged ulcer tissue and protects against acid and enzymes so healing can occur.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?Return to top
Sucralfate comes as a tablet and liquid to take by mouth. It usually is taken four times a day, 1 hour before meals and at bedtime. Take sucralfate on an empty stomach, 2 hours after or 1 hour before meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sucralfate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake liquid sucralfate well before measuring doses.
This medicine must be taken regularly to be effective. It may take up to 8 weeks for ulcers to heal.
Other uses for this medicineReturn to top
Sucralfate is also used to protect the stomach lining when taking aspirin and for mouth sores that occur with cancer chemotherapy. Talk to your doctor about the possible risks of using this drug for your condition.
What special precautions should I follow?Return to top
Before taking sucralfate,
* tell your doctor and pharmacist if you are allergic to sucralfate or any other drugs.
* tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids (Mylanta, Maalox), anticoagulants ('blood thinners') such as warfarin (Coumadin), cinoxacin (Cinobac), ciprofloxacin (Cipro), digoxin (Lanoxin), enoxacin (Penetrex), ketoconazole (Nizoral), levofloxacin (Levaquin), lomefloxacin (Maxaquin), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), phenytoin (Dilantin), quinidine, sparfloxacin (Zagam), tetracycline (Sumycin), and vitamins. If you are taking any of these medicines, do not take them within 2 hours of taking sucralfate.
* tell your doctor if you have or have ever had heart or kidney disease or diabetes.
* tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking sucralfate, call your doctor.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?Return to top
Although side effects from sucralfate are not common, they can occur. To avoid constipation, abdominal pain, and gas, eat a high-fiber diet (extra fruits, vegetables, salads, and bran) and drink plenty of fluids.
If you experience any of the following symptoms, call your doctor immediately:
* passing red or black stools
* coughing up or vomiting material that is bright red or looks like coffee grounds
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?Return to top
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to sucralfate.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Brand namesReturn to top
* Carafate"
haldolplz replied: "Sucralafate and domperidone shouldn't interact at all. You can take them at the same time or at separate times, depending on your situation.
This information is from MicroMedex, a program that I use in a hospital pharmacy.
I checked the links already posted, and it doesn't look like domperidone is listed at any of the sites.
Domperidone is a Canadian drug that isn't available in the U.S., so a Canadian pharmacist (chemist?) will be able to help you as well."
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